After a single 60-minute time intravenous infusion of 200 mg ofloxacin mean maximum plasma concentration of 2.7 mcg / mL; 12 hours after the administration of the concentration equal to 0.3 mg / ml.Equilibrium concentrations achieved after administration of four buy testosterone propionate doses.
Mean peak and minimum equilibrium concentration achieved following intravenous administration of 200 mg of ofloxacin every 12 hours for 7 days, and are 2.9 and 0.5 ug / ml, respectively.
Ofloxacin widely penetrate many liquid and body tissues, including saliva, bronchial secretions, bile, cerebrospinal fluid and tear, pus, lung, prostate and skin. Ofloxacin undergoes a partial (5%) metabolised in the liver.
Plasma protein binding is 20-25%. The half-life is 6-7 hours ofloxacin. Up to 80% of ingested drug is excreted by the kidneys in an unmodified form, a small part of the active substances are also excreted in the feces.
In patients with impaired renal function (creatinine clearance of 50 mL or less) increases the half-life of ofloxacin.
Hypersensitivity, deficiency of glucose-6-phosphate dehydrogenase, epilepsy (including history), lowering the seizure threshold (including after craniocerebral trauma, stroke or inflammation in the central nervous system); age up to 18 years (not yet completed skeletal growth), pregnancy, lactation.
Precautions – cerebral atherosclerosis, cerebrovascular accidents (in history), chronic renal failure, organic lesions of the central nervous system.
Dosing and Administration
Intravenously. Doses are selected individually depending on the location and severity of the infection and the sensitivity of micro-organisms, the general condition of the patient, and liver and kidney function.
Intravenous drip start with a single dose of 200 mg, administered slowly over a period of 30-60 minutes. With improvement of the patient is transferred to oral administration of the same daily dose.
Urinary tract infections – 100 mg 1-2 times a day, kidney and genital infections – 100 mg 2 times a day up to 200 mg two times a day, infection respiratory tract and upper respiratory tract, skin and soft tissue infections, bone and joint infections, abdominal infections, bacterial enteritis, septic infections – 200 mg 2 times a day. If necessary, the dose was increased to 400 mg 2 times a day.
For the prevention buy testosterone propionate of infections in patients with severe depression of immunity – 400-600 mg / day.
If necessary / drip – 200 mg 5% glucose solution. The duration of infusion -30 min. Only fresh solution should be used.
Patients with impaired renal function (when creatinine clearance (CC) 50-20 mL / min), the single dose should be 50% of the average doses for the multiplicity of 2 times a day, or a full single dose is administered 1 time per day. When CC less than 20 ml / min, single dose – 200 mg, then – 100 mg a day every other day.
In hemodialysis and peritoneal dialysis -. 100 mg every 24 hours maximum daily dose in hepatic impairment – 400 mg / day.
Side effects From the digestive system : gastralgia, anorexia, nausea, vomiting, diarrhea, flatulence, abdominal pain, increased activity of “liver” transaminases, hyperbilirubinemia, cholestatic jaundice, pseudomembranous enterocolitis. From the nervous system: headache, dizziness, lack of movement, tremors, convulsions, numbness and paresthesias of extremities, intense dreams, “nightmarish” dream, psychotic reactions, anxiety, agitation, phobias, depression, confusion, hallucinations, increased intracranial pressure. From the musculoskeletal system: tendinitis, myalgia, arthralgia ., tenosynovitis, tendon rupture From the senses: violation of color vision, diplopia, disturbances of taste, smell, hearing and balance. with the cardiovascular system: tachycardia, decreased blood pressure buy testosterone propionate (with on / in the introduction, with a sharp decrease in blood pressure introduction stop), vasculitis, collapse. allergic reactions: skin rash, pruritus, urticaria, hypersensitivity pneumonitis, allergic nephritis, eosinophilia, fever, angioedema, bronchoconstriction, Stevens-Johnson syndrome and toxic epidermal necrolysis, photosensitivity, erythema multiforme exudative, anaphylactic shock.
With the skin: petechial hemorrhages (petechiae), dermatitis bullous hemorrhagic, papular rash with crusted showing vascular involvement (vasculitis). from the side of hematopoiesis: leukopenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, hemolytic and aplastic anemia. from the urinary system: acute interstitial nephritis, renal dysfunction, hypercreatininemia, elevated levels of urea. Other: goiter, superinfection, hypoglycemia (in patients with diabetes), vaginitis. Local reactions: pain, redness at the injection site, thrombophlebitis (with on / in the introduction) .
Symptoms: dizziness, confusion, lethargy, disorientation, drowsiness, and vomiting.
Treatment: gastric lavage, symptomatic therapy.
Interaction with other medicinal products
is compatible with the following infusion solutions: isotonic sodium chloride solution, Ringer’s solution of sodium, 5% solution of fructose, 5% dextrose solution.
Do not mix with heparin (risk of precipitation).
Decreases theophylline clearance by 25% (while the application should be reduced dose theophylline).
cimetidine, furosemide, methotrexate and drugs that block tubular secretion – increase the concentration of ofloxacin in plasma.
Increases concentration of glibenclamide in plasma.
When concomitantly with vitamin K antagonists is necessary to control blood buy testosterone propionatecoagulation.
in the appointment of non-steroidal anti-inflammatory drugs, derivatives nitroimidazole and methylxanthines increases the risk of neurotoxic effects.
When concomitant administration with corticosteroids increases the risk of tendon rupture, particularly in the elderly.
in the appointment of agents, alkalizing urine (carbonic anhydrase inhibitors, citrate, sodium bicarbonate), increases the risk of crystalluria and nephrotoxic effects.
is not the drug of choice for pneumonia caused by pneumococcus. Not indicated in the treatment of acute tonsillitis.
It is not recommended to use more than 2 months, exposed to sunlight, ultraviolet radiation (mercury-quartz lamp, solarium).
In case of any side effects on the central nervous system, allergic reactions, pseudomembranous colitis requires removal of the drug . If pseudomembranous colitis, confirmed by colonoscopy and / or histologically demonstrated oral administration of vancomycin and metronidazole.
Rarely occurring tendinitis can lead to tendon rupture (predominantly Achilles tendon), particularly in elderly patients. In the event of signs of tendonitis, you must immediately discontinue treatment, to produce immobilization of the Achilles tendon and consult a podiatrist.
In the period of treatment should refrain from driving motor vehicles and activities potentially hazardous activities that require high concentration and psychomotor speed reactions, can not use ethanol.
In applying the drug to women is not recommended to use tampons, due to the increased risk of developing thrush.
The treatment possible worsening of myasthenia gravis, frequent attacks of porphyria in predisposed patients.
It may lead to false negative results when bacteriological diagnosis of tuberculosis (prevents the release of Mycobacterium tuberculosis). alpha pharma healthcare