The antibacterial activity of ofloxacin relates mainly to the L-isomer. As an antibacterial drug class of fluoroquinolones, levofloxacin blocking DNA gyrase and topoisomerase IV, testosterone cypionate vs propionate gives supercoiling and crosslink DNA breaks, inhibits DNA synthesis, causes profound morphological change in the cytoplasm, the cell wall and membranes . Effective against:
- Gramotritsatelnyh aerobes:
- Branhamella (Moraxella) catarrhalis
- Haemophilus influenzae
- Neisseria gonorrhoeae
- Pseudomonas aeruginosa
- Gram-positive aerobes:
- Staphylococcus aureus
- Streptococcus pneumoniae
- Streptococcus pyogenes
After installation in the eye levofloxacin is well maintained in the tear film. In studies in healthy volunteers have shown that the average concentration of levofloxacin in the tear film, as measured at 4 and 6 hours after topical application amounted to 17.0 ug / ml and 6.6 ug / ml, respectively. Five of the six subjects levofloxacin concentrations were 2 mg / ml or higher after 4 hours after installation.
In four of the six subjects remained after this concentration 6 hours after installation. The average concentration of levofloxacin in the application Oftakviks eye drops in the aqueous humor was significantly higher than the average concentration of ofloxacin. Maximum concentrations of levofloxacin achieved at day 15, more than 1000 times lower than the concentrations that have been observed after ingestion of standard doses of levofloxacin.
- at the age of 1 year treatment of superficial bacterial infections of the eyes of patients and older;
- Prevention of complications after surgical and laser eye surgery.
Hypersensitivity to any component of the formulation or to other quinolones, pregnancy, lactation.
Dosing and dose
Locally in the affected eye.
1-2 drops in the affected eye (s) every two hours up to 8 times per day during wakefulness during the first 2 days, then four times daily for 3 to 5 days . Duration of treatment is determined by a physician, usually 5 days.
Side testosterone cypionate vs propionate effects may occur in approximately 10% of patients. Common side effects (1-10% of patients): Burning sensation in the eye, blurred vision and the appearance of mucous strands. Rare side effects (0.1-1% of patients): Blepharitis, chemosis, papillary growths on the conjunctiva, swelling of the eyelids, unpleasant sensation in the eye, itching of the eye, eye pain, conjunctival hyperemia, appearance of follicles in the conjunctiva, the syndrome of “dry” eyes, erythema of eyelid, irritation, contact dermatitis, photophobia, and allergic reactions. Among other reactions which are observed during the clinical trials were headache and rhinitis.
Total levofloxacin contained in one bottle of eye drops too low to cause toxic reactions even after accidental ingestion. After topical administration of an excess dose eye drops Oftakviks, 5 mg / ml, the eye should be rinsed with clean (tap) water at room temperature.
Interaction with other medicinal products
for Advanced Studies on the interaction of eye drops Oftakviks, 5 mg / ml, was conducted. Because the maximum concentration in plasma levofloxacin after topical application in the eye at least 1000 times lower than after ingestion of standard doses into interaction with other drugs for systemic use characteristic likely clinically insignificant.
Eye drops 5 mg / ml should not be administered subkonyunktivalno testosterone cypionate vs propionate and directly into the anterior chamber of the eye.
With the simultaneous use of other ophthalmic means the interval between instillation of at least 15 minutes.
Drops should not be used while wearing hydrophilic (soft) contact lenses in Due to the presence of benzalkonium chloride in drops. To avoid contamination of the dropper tip and solution, the tip of the dropper should not touch the eyelids and tissues around the eyes.