testosterone propionate cream

When applied topically in the form of eye drops, timolol reduce both normal and elevated intraocular pressure by decreasing the formation of intraocular fluid. It has testosterone propionate cream no influence on pupil size and accommodation.

The action of the drug is 20 minutes after instillation in the conjunctival cavity. The maximum decrease in intraocular pressure occurs within 1-2 hours and lasts for 24 hours.

The local application of timolol maleate rapidly penetrates the cornea. After instillation of eye drops maximum concentration of timolol in the aqueous humor of the eye is achieved in 1-2 hours.

80% timolol applied as eye drops, enters the systemic circulation by absorption through the vessels of the conjunctiva, the lacrimal and the nasal mucosa tract. Excretion of metabolites of timolol is carried out mainly by the kidneys.

In infants and young children the concentration of timolol as the active substance, substantially exceeds its maximum concentration (C max ) in adult blood plasma.

Indications for use
– increased intraocular pressure (ocular hypertension);
– open-angle glaucoma;
– Glaucoma on afakicheskom eye and other secondary glaucoma;
– as an additional means for reducing the intraocular pressure in angle-closure glaucoma (in combination with miotikami)
– congenital glaucoma (in ineffectiveness of other means).

Contra-indications
– asthma or other severe chronic obstructive airway disease;
– sinus bradycardia;
– atrioventricular block II – III degree;
– decompensated heart failure;
– degenerative processes in the cornea;
– Children up to age 18 years (due to lack of data on the effectiveness of and drug safety in children and adolescents under 18 years)
– the allergic reaction to the drug components.

With caution
in patients with pulmonary insufficiency, severe cerebrovascular insufficiency, congestive heart failure in the stage of compensation, hypotension, diabetes, hypoglycemia, thyrotoxicosis, myasthenia, Raynaud’s syndrome, pheochromocytoma, atrophic rhinitis, as well as the simultaneous appointment of other beta-blockers, and psychoactive drugs drugs that enhance the release of epinephrine.

Pregnancy and lactation
sufficient experience of use of the drug during pregnancy, breast-feeding is not, however, found that timolol passes the placental barrier and enters the breast milk. By appointment physician Oftan® Timolol can be used during pregnancy and while breast-feeding unless the expected therapeutic effect for the mother justifies the potential risk to the fetus and child.

If the drug is used just before birth or during breastfeeding, the newborn should be closely monitored for several days after birth and during the entire treatment period, lactating mothers Oftan® drug timolol.

Dosing and Administration
at the beginning of treatment, 1-2 drops of the drug  timolol 2.5 mg / ml or 5.0 mg / ml in the affected eye 2 times a day.
If the intraocular pressure is normal with regular use, you should reduce the dose to 1st 1 drops once a day in the morning.
Treatment testosterone propionate cream timolol is generally performed for a prolonged time. A break in the treatment or change the dosage of the drug are made only by order of the physician.

Side effects:
Local reactions:
blurred vision, irritation and conjunctival hyperemia, burning and itchy eyes, watery eyes, swelling of the corneal epithelium, superficial punctate keratopathy, corneal gipostezii, “dry eye” syndrome, blepharitis, conjunctivitis and keratitis. With prolonged use may develop ptosis, and rarely – diplopia. During the fistuliziruyuschih (penetrating) antiglaukomatoznyh operations may develop choroidal detachment in the postoperative period.

Systemic reactions:
Cardiovascular system: bradycardia, bradyarrhythmia, decreased blood pressure, collapse, heart block, transient ischemic attacks, exacerbation of chronic heart failure.

Respiratory system: dyspnea, bronchospasm, pulmonary insufficiency.

Central nervous system: headache, dizziness, weakness, confusion, hallucinations, insomnia, onirodiniya, anxiety, mood changes.

Allergic reactions: generalized or local skin rashes, itching.

Skin: alopecia, psoriasiform rash and exacerbation of psoriasis.

Urogenital: Peyronie’s disease

Other systemic reactions: paresthesia, nasal obstruction, myasthenia gravis, decreased potency, nausea, diarrhea, chest pain, ringing in the ears.

In case of side effects, it should be as soon as possible, contact your doctor.

Overdose
may develop systemic testosterone propionate cream effects typical of beta-blockers: dizziness, headache, arrhythmia, bradycardia, bronchospasm, nausea, and vomiting.
Treatment: Immediately rinse eyes with water or saline solution, symptomatic therapy.

Interaction with other medicinal products and other forms of interaction
Sharing l eye drops containing adrenaline may cause mydriasis.

The specific effect of the drug – a decrease in intraocular pressure, which may be exacerbated by the simultaneous use of eye drops containing epinephrine and pilocarpine.

Two different beta-blockers should not be instilled into the same eye.

Hypotension and bradycardia may worsen while using Oftan® Timolol with calcium antagonists, reserpine and systemic beta-blockers.

CYP2D6 inhibitors such as quinidine and cimetidine, may increase the concentration of timolol in plasma.

Concomitant use with insulin or oral antidiabetic agents may lead to hypoglycemia.

Timolol increases the effects of muscle relaxants, therefore requires removal of the drug 48 hours before planned surgery with general anesthesia.

These data may relate to drugs that have been applied shortly before.

Cautions
blurred vision, dizziness and fatigue may occasionally occur with the use of timolol eye drops . During the period of treatment must be careful when driving and during work with complex equipment that require high concentration of attention, psychomotor speed reactions and good vision (for 0.5 hours after instillation of the eye), since the drug can reduce blood pressure, cause fatigue and dizziness.Monitoring the effectiveness of recommended about 3-4 weeks after initiation of therapy (not earlier than 1-2 weeks). Prolonged use may weaken the effect of timolol.

In the application it is necessary to control slezovydeleniya function, condition of the cornea and to evaluate the value of the fields of view of at least 1 time in 6 months.

Testosterone propionate cream contains the preservative benzalkonium chloride which can cause eye irritation, absorbed by soft contact lenses, causing discoloration and have an adverse effect on the eye tissue. Contact lenses should be removed before using the product and, if necessary, put them again no earlier than 15 minutes after instillation.

When transferring patients to treatment with timolol may need correction of refractive changes caused by previously used miotikami.

Like other beta-blockers may mask the possible low blood sugar symptoms in patients with diabetes.

In the case of the upcoming surgery under general anesthesia, it is necessary to cancel the drug 48 hours before surgery, as enhances the action of neuromuscular blocking agents and general anesthetics. testorapid