Omeprazole is rapidly absorbed from the gastrointestinal tract, the maximum concentration is reached after 0.5-1 hours in plasma. Bioavailability is 30-40%. Communication with plasma proteins – about 90%. Testosterone propionate cyclee is almost completely metabolized in the liver. The half – 0.5-1 hour. Write mainly kidneys as metabolites. In chronic renal insufficiency excretion is reduced in proportion to the decrease in creatinine clearance. In elderly patients deducing decreases, bioavailability increases. When liver failure bioavailability – 100%, half-life -3 hours.
- Gastric ulcer and duodenal ulcer (in the acute phase and anti-treatment), incl associated with Helicobacter pylori (in the complex therapy)..;
- Reflux esophagitis;
- Erosive-ulcerative lesions of gastric and duodenal ulcers associated with nonsteroidal anti-inflammatory drugs (NSAIDs);
- Ellison – Syndrome Zollinger.Contraindications:
Hypersensitivity to the drug, children’s age, the period of lactation.With care – renal and / or hepatic impairment.
Use during pregnancy
Use of omeprazole during pregnancy possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
Dosing and Administration
Inside, squeezed a small amount of water (the contents of the capsule should not be chewed). Duodenal ulcer exacerbation -. At 20 mg daily for 2-4 weeks (in resistant cases up to 40 mg per day) Peptic ulcer in exacerbation and erosive and ulcerative esophagitis – on 20-40 mg daily for 4-8 weeks. erosive and ulcerative lesions of the gastrointestinal tract caused by NSAID – 20 mg daily for 4-8 weeks.Helicobacter pylori eradication – 20 mg 2 times a day for 7 or 14 days (depending on the applied regimen) in combination with antibacterial agents. anti-treatment of gastric ulcer and 12 duodenal ulcer -. 20 mg a day of anti-treatment of reflux esophagitis – 20 mg per day for long periods (up to 6 months). Receiving the request (symptomatic treatment). Zollinger-Ellison Syndrome – dose selected individually depending on the initial level of gastric secretions, typically from 60 mg per day. If necessary to increase the dose of 80 -120 mg per day, in which case it is divided into 2 doses. Patients with severe hepatic insufficiency daily dose should not exceed 20 mg.
In rare cases, testosterone propionate cycle there may be the following, usually reversible side effects: On the part of the digestive system: diarrhea or constipation, nausea, vomiting, flatulence, abdominal pain, dry mouth, taste disturbances, stomatitis, transient increase in the level of “liver” enzymes plasma; in patients with previous severe liver disease – hepatitis (including jaundice..), abnormal liver function. From the nervous system: headache, dizziness, agitation, drowsiness, insomnia, paresthesias, depression, hallucinations; in patients with severe concomitant somatic diseases, patients with previous severe liver disease – encephalopathy. From the musculoskeletal system: muscle weakness, myalgia, arthralgia. Hematopoietic system: leukopenia, thrombocytopenia; in some cases – agranulocytosis, pancytopenia. For the skin: itching; rarely, in some cases – photosensitivity, erythema multiforme, alopecia. Allergic reactions: urticaria, angioedema, bronchospasm, interstitial nephritis and anaphylactic shock. Other: visual disturbances, peripheral edema, sweating, fever, gynecomastia; seldom – formation of gastric glandular cysts during long-term treatment (a consequence of inhibiting the secretion of hydrochloric acid, is benign, reversible).
symptoms: blurred vision, drowsiness, agitation, confusion, headache, increased sweating, dry mouth, nausea, arrhythmia. There is no specific antidote. Treatment is symptomatic. Hemodialysis is not effective enough.
The interaction with other drugs
Prolonged use of omeprazole 20 mg 1 time per day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not change concentration in plasma .
There was no interaction with simultaneously take an antacid. It may reduce the absorption of penicillin esters, iron salts, itraconazole and ketoconazole (omeprazole increases gastric pH). As an inhibitor of cytochrome P450, may increase the concentration and reduce the excretion of diazepam indirect anticoagulants, phenytoin (drugs that are metabolized in the liver by cytochrome CYP2C19), which in some cases may require reducing the dose of these drugs. It enhances inhibitory action on other testosterone propionate cycle hemopoietic system drugs.
Before therapy is necessary to exclude the presence of malignant process (especially gastric ulcer), t. To. The treatment, masking symptoms, may delay correct diagnosis.
The reception at the same time with food does not affect its efficiency.
If you have trouble swallowing whole capsules can swallow the contents after opening or resorption of the capsule, and can mix the contents of the capsule with slightly acidified liquid (juice, yogurt), and use the resulting suspension for 30 min.
in patients with severe liver failure daily dose should not exceed 20 mg.
in conventional drug dosages no effect on psychomotor reactions rate and concentration.