Protein interacts with a specific receptor in target tissues, regulates the expression of genes kortikoidzavisimyh and thus influences on the synthesis of protein.Stabilizes lysosomal enzymes of leukocytes membranes; inhibits the synthesis of kinins, mitosis and migration of leukocytes; It inhibits the synthesis of antibodies and antigen recognition breaks. All these effects are involved in the suppression of the inflammatory response in testosterone propionate results tissues in response to mechanical, chemical or immune damage. The duration of anti-inflammatory action after instillation of one drop of solution is from 4 to 8 hours.
When applied topically, systemic absorption – low. After instillation in the conjunctival sac penetrates well into the epithelium of the cornea and conjunctiva;wherein the aqueous humor of the eye in therapeutic concentrations are achieved; in inflammation or damage to the mucous membrane penetration rate increases. About 60-70% of dexamethasone entering the systemic circulation, is bound to plasma proteins. It is metabolized in the liver by the action of cytochrome P450 enzymes containing (CYP3A4); metabolites are excreted through the intestines. The half-life in plasma (t1 / 2) averaged 3.6 ± 0.9 hours.
Acute and chronic inflammatory processes:
– Purulent forms of conjunctivitis, keratitis, keratokonyuktivita without damage to the epithelium and blepharitis;
– scleritis and episcleritis;
– iritis, iridocyclitis and other uveitis of various origins;
– superficial corneal damage of various etiologies (chemical, physical, or immune mechanisms) after complete epithelialization of the cornea;
– inflammation posterior segment of the eye (choroiditis, chorioretinitis);
– sympathetic ophthalmia.
Allergic diseases of the eye:
– Allergic conjunctivitis and keratoconjunctivitis.
Prevention and treatment of postoperative inflammation and posttraumatic period.
– Keratitis associated with herpes simplex, varicella and other viral diseases of the cornea and conjunctiva;
– tuberculosis eye;
– mycobacterial infections of the eye;
– fungal diseases of the eye;
– acute purulent eye diseases;
– damage to the corneal epithelium (including the state after remove foreign cornea body);
– epitheliopathy cornea;
– increased intraocular pressure;
– children up to age 18 years (due to lack of data on efficacy and safety in children and adolescents under 18 years of age)
– hypersensitivity to any of the components drug.
Pregnancy and lactation
To date, clinical trial data on the use of the drug Oftan® Dsksametazon during pregnancy, lactation are not available. Oftan Dsksamstazon can be used during pregnancy and during breast grudyo only prescribed by a doctor, unless the expected therapeutic effect justifies the potential risk to the fetus and child.
Duration of treatment: no more than 7-10 days.
Dosage and administration:
In acute conditions: 1-2 drops into the conjunctival sac every 1-2 hours.
After reducing inflammation eyedrops testosterone propionate results 1-2 drops instilled in the conjunctival sac of 3-5 times per day.
The duration of treatment with eye drops should not exceed 2-3 weeks.
The decision on the duration of treatment is based on objective data, including the effectiveness of the drug, clinical symptoms and the potential risk of side effects.
after instillation of eye drops may occur rapidly undergoing a burning sensation, allergic reactions.
Long-term use (more than 3 weeks) dexamethasone can cause secondary glaucoma and steroid cataract, as well as possible ulceration, blurred, thinning or perforation of the cornea; in rare cases, dexamethasone can promote the spread of herpes and bacterial infections.
Oftan® Dexamethasone contains in its composition the preservative benzalkonium chloride which may cause eye irritation.
In case of side effects, as soon as possible to contact your doctor.
An overdose of the local application of eye drops is unlikely.
Symptoms. Possible local irritation
is no specific antidote. The drug should be withdrawn and symptomatic therapy.
The interaction with other drugs
interaction with other drugs, mainly due to the participation in the removal of dexamethasone containing enzyme cytochrome P450 (CYP3A4). It induces CYP3A4 enzyme, thereby reducing the effectiveness of calcium channel blockers, quinidine and erythromycin. In normal mode, a topical dose sufficient to cause saturation induction or hepatic enzyme.
Prolonged use may increase with yodoksuridinom destructive processes in the epithelium of Rogovin.
Oftan® Dexamethasone contains in its composition a preservative benzalkoiiya chloride which may be absorbed by soft contact lenses and cause discoloration and have an adverse effect on the eye tissue.If you want to use contact lenses during treatment with testosterone propionate results, they should be removed before using the product and put not earlier than 15 minutes after instillation, if necessary.
During treatment with more than 2 weeks, it is necessary to regularly monitor the intraocular pressure and corneal condition.
Corticosteroid therapy can mask the current bacterial or fungal infection. In the presence of infection should be combined with the use of appropriate antimicrobial drops tepapiey.
In view of a possible watery eyes after instillation of the drug is not recommended immediately before driving of the vehicles or operating mechanical equipment. buyanabolics