what is testosterone propionate

In the preparation, storage and administration of the drug, Paclitaxel Ebewe equipment should be used which does not contain polyvinyl chloride (PVC), for example glass, polypropylene or polyolefin. A solution concentrate formulation is prepared dilution to a final paclitaxel concentration of 0.3 to 1.2 mg / ml. As what is testosterone propionate a diluting solution may be used: 0.9% sodium chloride solution, 5% dextrose, 5% dextrose in 0.9% sodium chloride solution, 5% dextrose in Ringer’s solution. Opalescent solutions may be prepared for the composition present in the dosage form of the carrier substrate. With the drug should be used with the system of a membrane filter (pore size less than 0.22 microns).

Infusion solutions prepared by diluting Paclitaxel Ebewe-0.9% sodium chloride or 5% dextrose sodium are physically and chemically stable for 51 hours if stored at a temperature of 25 ° C and 14 days when stored at 5 ° FROM. From a microbiological point of view, the solution for infusion should be administered immediately after preparation. If the solution is not used immediately after preparation, storage time should not exceed 24 hours at 2-8 ° C, if the solution is prepared under controlled aseptic conditions.

To reduce the precipitation risk for infusion solution should be administered immediately after reconstitution and avoiding excessive shaking, vibrations and shaking. Infusion system must be thoroughly rinsed before use. During the introduction, you should regularly monitor the appearance of the solution, and when it detects sludge to stop the infusion.

Possible side effects when used
are dose-dependent incidence and severity of side effects.

The frequency of side effects is set out in accordance with the following gradation:
very often – more than 10%, and some – from 1 to 10%, not often – from 0.1% to 1%, rare – from 0.01 to 0.1%, a very rare – less than 0.01%.

From the blood system and lymphatic system Very common: myelosuppression, neutropenia, thrombocytopenia, anemia, leukopenia, bleeding; rare: febrile neutropenia; very rare: acute myeloid leukemia, myelodysplastic syndrome.

The nervous system is very frequent: neurotoxic effects (mainly peripheral neuropathy), paraesthesia; Rare: motor neuropathy (moderately severe weakness of the what is testosterone propionate distal muscles, difficulty in performing precise movements); very rare: autonomic neuropathy (resulting in paralytic ileus and orthostatic hypotension), grand mal seizures ( «grand mal»), convulsions, encephalopathy, dizziness, headache, confusion, ataxia.

On the part of the cardiovascular system are frequent: bradycardia, decreased blood pressure; Uncommon: cardiomyopathy, asymptomatic ventricular tachycardia, atrioventricular block, syncope, hypertension myocardial infarction, thrombosis, thrombophlebitis Very rare: atrial fibrillation, supraventricular tachycardia, shock.

 

From the senses are very rare: the defeat of the optic nerve and / or visual disturbances (scintillating scotoma), hearing loss, tinnitus, vertigo.

The respiratory system rare: shortness of breath, pleural effusion, interstitial pneumonia, lung fibrosis, pulmonary embolism, respiratory failure, radiation pneumonitis in patients while undergoing radiation therapy; very rare: coughing.

From the digestive system is very frequent: nausea, vomiting, diarrhea, inflammation of the mucous membranes; rare: pancreatitis, intestinal perforation, ischemic colitis, very rare: anorexia, constipation, mesenteric thrombosis, pseudomembranous colitis, oesophagitis, ascites, neutropenic colitis, liver necrosis, hepatic encephalopathy (there are sporadic reports of deaths).

 

Skin and skin appendages Very common: alopecia Frequent: transient slight variations nails and skin (violation of pigmentation, discoloration of the nail bed); rare: itchy skin, rash, erythema, very rare:Stevens-Johnson syndrome (ulceration of the oral mucosa mouth, throat, eyes, genitals and other parts of the skin and mucous membranes), epidermal necrolysis, erythema multiforme, exfoliative dermatitis, urticaria, onycholysis.

On the part of the musculoskeletal system Very common: arthralgia, myalgia.

Immune system Very common: infection (mainly urinary tract and upper respiratory tract) are not frequent: serious hypersensitivity reactions, requiring therapeutic measures (namely, lower blood pressure, angioedema, respiratory distress syndrome, generalized urticaria, chills, back pain, chest pain, tachycardia, abdominal pain, pain in the limbs, expressed sweating, increased blood pressure); rare:anafilatoidnye reaction.

Laboratory findings are frequent: an increase in activity of “liver” transaminases, increased alkaline phosphatase, bilirubin, what is testosterone propionate serum creatinine.